Oxidative Stress Related Diseases in Newborns
نویسندگان
چکیده
منابع مشابه
Oxidative Stress Related Diseases in Newborns
We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced reactive oxygen/nitrogen species and the lack of protective ability of antioxidants. From that point of view, free radical-induced damage cause...
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1Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie 514-8507, Japan 2Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501-1196, Japan 3Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan 4Department of Ophthal...
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Oxidative stress corresponds to an imbalance between the rate of oxidant production and that of their degradation. The main biological targets of free radicals are proteins, lipids and DNA. Protein oxidation leads to loss of function or premature degradation in proteasomes. Lipid peroxidation, occurring mostly in the plasma membrane or the stratum corneumthe most superficial layer of the epider...
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The lungs of newborns are especially prone to oxidative damage induced by both reactive oxygen and reactive nitrogen species. Yet, these infants are often 1) exposed to high oxygen concentrations, 2) have infections or inflammation, 3) have reduced antioxidant defense, and 4) have high free iron levels which enhance toxic radical generation. Oxidative stress has been postulated to be implicated...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2016
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2016/2768365